By - Amber Dance, Edited by Amal Udawatta, Boys are four times as likely as girls to develop autism. Girls are nearly twice as likely to experience depression. The immune system may be a player in these and other brain-health disparities . CREDIT: SAM FALCONER Differences between the immune systems of males and females — in particular, ones involving cells called microglia — might help explain why the risk for conditions such as autism and Alzheimer’s varies between the sexes Suppose a couple has two children, a boy and a girl. Chances are, they’ll both grow up with typical, healthy brains. But should either diverge from the usual route of brain development, or suffer mental health issues, their paths are likely to be different. The son’s differences might show up first. All else being equal, he’s four times more likely than his sister to be diagnosed with autism . Rates of other neurodevelopmental conditions and disabilities are also higher in boys. As he grows into a young